DNA Celiac Disease Risk Test
easy-to-use mouth swabs
Most people with celiac disease carry at least one genetic risk variant for developing the disease. Learn more about your risk factors today.
Genetic Variants Tested:
- HLA-DQA1*05
- HLA-DQB1*02
- HLA-DQB1*0302
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$450.00
No hidden lab fees. Free return shipping included.
Get secure results through your private online portal.
All samples are tested twice for absolute accuracy.
Find out if you have Celiac disease-specific genes.
Greater than 95% of individuals with celiac disease have disease-specific genes. This Celiac Disease Home DNA Test analyzes four different genes associated with Celiac Disease.
Celiac disease is an autoimmune disease in response to the digestion of gluten, a protein found in wheat, barley, rye and other grains, and is commonly included in many processed and packaged foods. Each time an affected individual ingests gluten, their immune system reacts aberrantly and damages the lining of their small intestine. This intestinal damage inhibits the absorption of vitamins, minerals and nutrients, leading to a wide range of disease signs and symptoms.
Most affected individuals suffer from gastrointestinal symptoms including embarrassing flatulence, uncomfortable bloating, constipation, diarrhea, excessive weight loss, food intolerances and nausea. Prolonged damage to the intestinal lining also causes non-gastrointestinal symptoms such as fatigue, painful migraines, depression, musculoskeletal problems, skin rashes and vitamin deficiencies. Affected children may not grow and develop as normal and may have delayed puberty.
Genetic screening is a very useful step in diagnosing celiac disease, and it has the advantage that the patient does not need to be consuming gluten at the time that the DNA sample is taken.
All-inclusive testing, with no hidden fees
- All lab fees
- DNA Collection Kit Supplies and Swabs
- Free return shipping
- Certified lab reports
- 2x testing for accuracy
- Full customer service & support
What’s inside your kit?
What is Analyzed
This Celiac Disease Home DNA Test analyzes the following disease-associated alleles associated with Celiac Disease:
- HLA-DQA1*05, HLA-DQB1*02 and HLA-DQB1*0302
- Heterodimers DQ2 (encoded by HLA-DQA1*05 and HLA-DQB1*02) and/or DQ8 (encoded by HLA-DQA1*03 and HLA-DQB1*0302)
Over 95% of individuals with celiac disease have specific celiac disease-associated alleles in the HLADQA1 and HLA-DQB1 genes (HLA-DQA1*05, HLA-DQB1*02 and HLA-DQB1*0302). The presence of celiac disease-associated HLA alleles implies an increased risk for celiac disease, but is not diagnostic of celiac disease as only a subset of individuals with these alleles will develop celiac disease.
Exclusionary Alleles
Individuals who test negative for the celiac disease-associated alleles HLA-DQA1*05, HLA-DQB1*02 and HLA-DQB1*0302 can essentially exclude a diagnosis of celiac disease and have almost no lifetime risk of developing celiac disease (less than 0.04% chance), regardless of whether or not they ingest gluten.
Possible Allelic Combinations
Here are the possible allelic combinations and their associated risk factors:
| Patient Genotype (celiac diesease-associated alleles) | Celiac disease Risk* |
|---|---|
| DQ2 and DQ8 | 1:7 |
| DQ2 and Homozygous HLA-DQB1*02 | 1:10 |
| DQ2 and DQ2 | 1:10 |
| DQ8 and DQ8 | 1:12 |
| DQ8 and HLA-DQB1*02 | 1:24 |
| Homozygous HLA-DQB1*02 | 1:26 |
| DQ2 | 1:35 |
| DQ8 | 1:89 |
| Heterozygous HLA-DQB1*02 | 1:210 |
| Heterozygous HLA-DQA1*02 | 1:1842 |
| No celiac disease-associated HLA alleles detected | Not at risk of developing celiac disease, less than 1:2518 |
Find out if you have Celiac disease-specific genes.
Greater than 95% of individuals with celiac disease have disease-specific genes. This Celiac Disease Home DNA Test analyzes four different genes associated with Celiac Disease.
Celiac disease is an autoimmune disease in response to the digestion of gluten, a protein found in wheat, barley, rye and other grains, and is commonly included in many processed and packaged foods. Each time an affected individual ingests gluten, their immune system reacts aberrantly and damages the lining of their small intestine. This intestinal damage inhibits the absorption of vitamins, minerals and nutrients, leading to a wide range of disease signs and symptoms.
Most affected individuals suffer from gastrointestinal symptoms including embarrassing flatulence, uncomfortable bloating, constipation, diarrhea, excessive weight loss, food intolerances and nausea. Prolonged damage to the intestinal lining also causes non-gastrointestinal symptoms such as fatigue, painful migraines, depression, musculoskeletal problems, skin rashes and vitamin deficiencies. Affected children may not grow and develop as normal and may have delayed puberty.
Genetic screening is a very useful step in diagnosing celiac disease, and it has the advantage that the patient does not need to be consuming gluten at the time that the DNA sample is taken.
All-inclusive testing, with no hidden fees
- All lab fees
- DNA Collection Kit Supplies and Swabs
- Free return shipping
- Certified lab reports
- 2x testing for accuracy
- Full customer service & support
What’s inside your kit?
What is Analyzed
This Celiac Disease Home DNA Test analyzes the following disease-associated alleles associated with Celiac Disease:
- HLA-DQA1*05, HLA-DQB1*02 and HLA-DQB1*0302
- Heterodimers DQ2 (encoded by HLA-DQA1*05 and HLA-DQB1*02) and/or DQ8 (encoded by HLA-DQA1*03 and HLA-DQB1*0302)
Over 95% of individuals with celiac disease have specific celiac disease-associated alleles in the HLADQA1 and HLA-DQB1 genes (HLA-DQA1*05, HLA-DQB1*02 and HLA-DQB1*0302). The presence of celiac disease-associated HLA alleles implies an increased risk for celiac disease, but is not diagnostic of celiac disease as only a subset of individuals with these alleles will develop celiac disease.
Exclusionary Alleles
Individuals who test negative for the celiac disease-associated alleles HLA-DQA1*05, HLA-DQB1*02 and HLA-DQB1*0302 can essentially exclude a diagnosis of celiac disease and have almost no lifetime risk of developing celiac disease (less than 0.04% chance), regardless of whether or not they ingest gluten.
Possible Allelic Combinations
Here are the possible allelic combinations and their associated risk factors:
| Patient Genotype (celiac diesease-associated alleles) | Celiac disease Risk* |
|---|---|
| DQ2 and DQ8 | 1:7 |
| DQ2 and Homozygous HLA-DQB1*02 | 1:10 |
| DQ2 and DQ2 | 1:10 |
| DQ8 and DQ8 | 1:12 |
| DQ8 and HLA-DQB1*02 | 1:24 |
| Homozygous HLA-DQB1*02 | 1:26 |
| DQ2 | 1:35 |
| DQ8 | 1:89 |
| Heterozygous HLA-DQB1*02 | 1:210 |
| Heterozygous HLA-DQA1*02 | 1:1842 |
| No celiac disease-associated HLA alleles detected | Not at risk of developing celiac disease, less than 1:2518 |
Be Proactive With Your Health
Understanding your genetic risk provides you with the opportunity for early intervention and prevention through certain lifestyle changes.
Easy sample collection
Each kit contains painless, easy-to-use mouth swabs.
Quality assured
All testing is performed in our ISO 17025, AABB and CLIA certified laboratory.
Live status updates
Track the status of your order and view your results as soon as they are ready.
Private & confidential
Your data belongs to you. We do not share your data with any third party without your permission.
How it works
Collect & Send
Swab your mouth, then mail your samples to our lab. Free shipping included.
Get Results
Receive confidential results through your secure online portal.
FAQ
Answers to commonly asked questions about this test.
Celiac disease is an autoimmune disorder that affects the small intestine and is triggered by consuming gluten, a protein found in wheat, barley, and rye.
Not necessarily – this DNA test does not diagnose celiac disease, however it provides important insight into whether an individual is “at-risk” for Celiac Disease based on their genetic makeup.
If you test negative for celiac disease, you will not develop the disease in the future. This assists healthcare professionals in ruling out celiac disease in some cases.
However, if the genetic predisposition for celiac disease is detected in your genetics, this means you are “at-risk” for developing the disease and may develop it at any time. If your results show the presence of celiac disease causing alleles in your DNA, speak with your physician or healthcare provider about the next steps.
DNA testing begins immediately the day that your samples arrive at the laboratory and is completed within 2 to 4 weeks. In some special situations, additional testing may be required, which could increase the turnaround time by a few extra days. You can check the status of your test online 24/7 using your secure account login. Your test report is released immediately once testing is complete.
No. This test can be taken at any time, regardless of whether an individual has recently eaten or not. This test looks for the presence of specific alleles in your DNA, which is not impacted by what you recently ingested. Fasting is not necessary and will not affect the accuracy of results.
Once testing is complete, results are released immediately to your secure online portal where you may view, download or share your results with your physician or healthcare provider.
